The Farah Saeed Project

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Bone Cancer

Risk Factors Of Bone Cancer

Supporting Images and Videos

What is Li-Fraumeni Syndrome? By Dana-Farber Cancer Institute

Paget’s Disease – Pathology, Causes, Symptoms, Diagnosis, Treatment By One Post Medicine

Examples of bone-derived factors influencing organs (Li et al., 2019)
The role of bone-derived factors and how they cause hallmarks of cancer and affect bone homeostasis
The structure of the vertebrae
Types of degeneration of the discs
This is a group of muscles in the lower back that can be damaged due to overuse of medications
Smaller and larger nerves of the lower leg that can be damaged and irritated, especially in the lower back of the legs due to overuse of medications. Anterior (front view) and posterior (back view)

Cranial Nerves That Affect The Lower Leg

The structure of the spinal vertebrae
Structure of the adrenal glands that is linked to where corticosteroid hormone is produced and is a type of medication.

Glucocorticosteroid Mechanism of Action by Geneedinc

Recommended Reading

fact sheetDownload

References

Anatomy System (2026) Lower Limb Nerves. Available at: https://anatomysystem.com/lower-limb-nerves/ (Accessed: 5th May 2026)

Cancer Research UK (2025a) Types of bone cancer. Available at: https://www.cancerresearchuk.org/about-cancer/bone-cancer/types (Accessed: 3rd April 2026)

Li, Y., Yin, P., Guo, Z., Lv, H., Deng, Y., Chen, M., Gu, Y., Tang, P. and Zhang, L. (2019). Bone-Derived Extracellular Vesicles: Novel Players of Interorgan Crosstalk. Frontiers in Endocrinology, 10. doi:10.3389/fendo.2019.00846.

Pullan, J. and Lotfollahzadeh, S. (2024). Primary Bone Cancer. Available at: https://www.ncbi.nlm.nih.gov/books/NBK560830/ (Accessed: 9th April 2026)

Schierling, R. (2017) Fascial adhesions are a chief culprit in numerous chronic pain syndromes caused by cutaneous nerve entrapments. Available at:https://doctorschierling.com/blog/fascial-adhesions-are-a-chief-culprit-in-numerous-chronic-pain-syndromes-caused-by-cutaneous-nerve-entrapments (Accessed: 6th May 2026)

Science Insights (2026) What Spinal Nerves Affect the Legs: L1 to S3. Available at: https://scienceinsights.org/what-spinal-nerves-affect-the-legs-l1-to-s3/ (Accessed: 5th May 2026)

Soldatos, T., Andreisek, G., Thawait, G., Guggenberger, R., Williams, E., Carrino, J. and Chhabra, A. (2013) High-Resolution 3-T MR Neurography of the Lumbosacral Plexus. RadioGraphics 33 (4).

Updated July 2026 Next Review July 2028

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