Tag: ewingsarcoma
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The Role Of Col2a1a promoter in Ewing sarcoma
There have been several recent discoveries that have come to our attention, which significantly impact our understanding of bone cancer and open new avenues for detecting cancer, especially in cases where bone cancer is less likely to be linked to modifiable risk factors. Current risk factors for bone cancers arise from genetic conditions, chemical or…
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Adamantinoma FactFile
Overview of Adamantinoma Malignancy: Rare, slow-growing, malignant tumour Type of bone tumour: primary 0.3 to 1% of all primary bone tumours Grade: Low grade but can be treated surgically. Location: It originates from epithelial cells trapped in bone (intracortical) during development in mesenchymal (osteofibrous dysplasia-like) stroma. Lower leg: Diaphysis of Tibia (middle of shin bone) and…
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Giant Cell Tumour Of The Bone FactFile
Overview of Giant Cell Tumour Of The Bone Malignancy: Benign; aggressive; rarely metastasizes. 20% of benign skeletal tumours. Type of bone tumour: Primary 5% of all primary tumours Grade: Varies Location: Multiple Most lesions (75% to 90%) form on the extension of metaphysis into epiphysis of long bones. For instance, the frequent areas: distal femur (thigh…
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LeiomyosarcomaFactFile
Overview of Leiomyosarcoma Malignancy: Malignant mesenchymal tumours Aggressive and fast-growing Type of bone tumour: primary Grade: Varies Location: This type of sarcoma can either start in the soft tissue (smooth muscle) or bone, for instance, the femur as presented in the X-ray above. 10% to 20% of soft tissue sarcoma cases. 0.17% of all cancers. Smooth…
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Fibrosarcoma FactFile
Overview of Fibrosarcoma Malignancy: Rare and aggressive soft tissue malignancy. Type of bone tumour: Primary Grade: Varies Paediatric –> Slow-growing –> infantile or congenital fibrosarcoma. Adults and teenagers –> Adult form fibrosarcoma. Location: It originates from spindle-shaped fibroblasts found in tissue around tendons, ligaments and muscles (fascia). This type of sarcoma can either start in the…
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Chordoma FactFile
Overview of Chordoma Malignancy: very rare malignant Type of bone tumour: primary Grade: slow-growing/low grade Location: It affects the vertebral bodies. The vertebral bodies are the bony area of the spine rather than the jelly disc, though they contain vestigial notochord within the nucleus pulposus. The notochord is the early stage of the spine in a…
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Undifferentiated pleomorphic sarcoma (UPS) of the bone FactFile
Overview of Undifferentiated pleomorphic sarcoma (UPS) of the bone Other names: Previously called malignant fibrous histocytoma. Malignancy: Malignant and fast-growing mesenchymal tumour. Type of bone tumour: Primary Grade: High and can metastasize in 50% of cases. Extremely rare (2 – 6% of all primary malignant bone tumours. Location: Long bones: femur (lower limb/thigh bone). Tibia and…
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Round Cell Sarcoma FactFile
Overview of Round Cell Sarcoma Malignancy: Malignant Type of bone tumour: Mesenchymal tumour Grade: Varies Location: Onset: Varies with type of round cell sarcoma Risk Factors Of Round Cell Sarcoma A) Genetics: EWSR1::NFATC2 and FUS::NFATC2 fusions EWS RNA-binding protein 1 (EWSR1) is a member of the FET or TET family and is found on chromosome…
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Chondrosarcoma FactFile
Overview of Chondrosarcoma Malignancy: Yes, a malignant bone tumour that originates from the cartilage cells. Type of bone tumour: Most common primary tumour Grade: Most are low grade 10% of low-grade tumours transform to higher grades 90% of patients with Grade 1 have a 5-year survival, and is decreased to 40% in patients with Grade 3…
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